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-synuclein, which happens to be a primary part of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, that is an E3 ubiquitin ligase and will cause endoplasmic reticulum (ER) anxiety, advise that dysfunction with the intracellular proteinase units, like ubiquitin-proteasome process or lysosomal system, which gets rid of avoidable poisono